As the director of the Center for Thrombosis Research at Sinai Hospital of Baltimore (SCTR), Paul A Gurbel, MD's research has sparked a much needed debate in the cardiology community surrounding the under-recognized role that platelets play in coronary thrombosis and the efficacy of conventional antiplatelet treatment. His translational research has influenced treatment guidelines and the design of prospective large scale clinical trials. A major focus of his laboratory is new drug development, for which his Center has received NIH funding. Within the Center is a dedicated phase I facility, where first-in-human and early phase studies are conducted.